Povestea mafiotului italiano-american Tony Soprano din New Jersey și dificultățile cu care se confruntă în încercarea de a echilibra cerințele conflictuale ale vieții sale de acasă și organizația infracțională pe care o conduce. Aceste dificultăți sunt adesea evidențiate prin relația sa profesională continuă cu psihiatrul Jennifer Melfi. Legătura complexă cu soția sa Carmela, copiii adolescenți, unchiul (fratele tatălui său) care nu îl consideră șef și i se opune în toate privințele, la aceste probleme personale se adaugă cele „de muncă”, în care Tony trebuie să jongleze cu FBI, trădătorii din propria familie și șefii în ascensiune din familii rivale.
Phil Leotardo seeks to continue a cycle of retaliation between the New York and Jersey families. Christopher wrestles with his addictions. Tony decides keeping Carmela occupied with the spec house is for the best. A.J. gets a new girlfriend.
Bobby and Janice host a wild 47th birthday bash for Tony at their Adirondacks vacation home. Tony's actions following Johnny Sack's arrest come back to haunt him.
Christopher's Cleaver premieres, showing Tony how he feels about him. Johnny Sack faces a health crisis. Phil Leotardo resents his family, and himself, for being weak and downtrodden. Silvio gets caught up in New York's power vacuum.
When Tony's first hit is about to be unearthed, he and Paulie flee to Florida, where Tony contemplates their friendship. Junior organizes a poker game at the institution. The New York power struggle continues.
The Soprano and Lupertazzi crime families quarrel over asbestos removal. Tony deals with a problematic associate. Paulie suffers a devastating personal loss. A.J. questions his friendship with Jasons Parisi and Gervasi.
Tony attempts to repair the rift between New Jersey and New York. A.J.'s depression struggle continues. A New York associate crosses the line with Meadow.
The spectre of disloyalty among the crew hangs over Tony as Phil Leotardo decides how to handle recent issues with the Soprano crime family. A hit gone wrong comes at a huge cost. A.J.'s conquering of his depression is challenged.
Tony seeks to find a peace with the Leotardo crew while dealing with rumors a member of his own crew may have flipped. A.J. makes a decision regarding his future and Junior's slide into dementia continues.
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