Cu locația în Springfield, orașul tipic american, povestea se concentrează pe aventurile ridicole ale familiei Simpson; Homer, Marge, Bart, Lisa și Maggie, dar și pe o distribuție de alte câteva sute de personaje.
De la început, seria a devenit un simbol cultural, atrăgând sute de vedete care și-au făcut apariția ca invitați. Serialul și-a făcut un nume prin satira fără frică asupra politicii, mediei și vieții americane în general.
After Homer humiliates himself in a town meeting, he looks for acceptance in an internet group hunting for a missing tortoise but finds something much more sinister.
Marge is hired as a segment producer on Krusty's new daytime talk show. But her initial excitement about the job fades when she discovers what an endless nightmare it is!
In a book-themed trilogy, Marge's resentment takes monstrous form, Lisa tries to save the planet through murder and Homer learns he's not the man he thought he was.
Homer is stunned by his feelings of rage and resentment when Grampa becomes a doting stepfather to his girlfriend's quirky young son. Lisa and Bart throw the ultimate slumber party.
When Bart discovers a profitable glitch in an online game, he ropes Principal Skinner into his lucrative criminal enterprise. Marge and Maggie discover paradise.
When Bart's latest prank leads to chaos at Springfield Elementary, Marge and Homer dream of a world in which their rambunctious son was never a Simpson.
When Milhouse's Dad, Kirk, takes exception to a school history lesson that paints one of his ancestors in a bad light, Kirk goes on a crusade to censor and control the school curriculum -- a crusade that Homer co-opts for fun and profit.
Time stands still after Homer crashes his car and flies through the windshield. As his life flashes before his eyes, a magical friend helps Homer learn the secret truth about his marriage.
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