Adevărul e undeva acolo și agenții FBI îl caută în acest serial sci-fi despre misiunea lor de a explica ce pare imposibil de explicat. Cazurile ciudate includ observarea OZN-urilor, întâlniri și răpiri extraterestre și orice altceva paranormal.
While the Cigarette-Smoking Man recites to an unseen listener everything about the work of the Syndicate involving a global conspiracy in cooperation with an alien species, Cassandra Spender reappears and is pursued by the scientists who would rather kill her than keep her alive. Cassandra runs to Mulder's apartment and demands that he shoot her because she is the culmination of 50 years work - a living alien/human hybrid - and colonization will begin if the aliens find out about her.