A Las Vegas team of forensic investigators are trained to solve criminal cases by scouring the crime scene, collecting irrefutable evidence and finding the missing pieces that solve the mystery.
Grissom investigates when a woman vanishes while taking part in a magician's act. The female volunteer is placed inside the Amazing Zephyr's "Chamber of Doom" and the illusionist thrusts swords through the box. When it's opened, she's gone---and doesn't reappear in her seat as she's supposed to. Only traces of blood are left inside the chamber. Clues lead the CSIs to an eerie, decrepit mansion filled with secrets. Elsewhere, a rock star's death on a band bus appears to be the result of an overdose, but Catherine uncovers evidence that points to murder.