A Las Vegas team of forensic investigators are trained to solve criminal cases by scouring the crime scene, collecting irrefutable evidence and finding the missing pieces that solve the mystery.
A serial killer strikes again, and the CSI team tries new technology using evidence from a prior killing. They find a fingerprint belonging to Jesse Acheson, who becomes the prime suspect. A boy confesses to the killing of his brother, but evidence suggests that he may not have committed the crime.