Viața cu Louie este un serial de desene animate în care sunt povestite întâmplări din viața lui Louie Anderson, un copil de 8 ani care trăiește în Cedar Knoll, Wisconsin (SUA). Louie mai are 5 frați și surori, dar aceștia nu apar în fiecare episod.
Deși are mulți prieteni, Louie are și un inamic pe nume Glen Glenn, care îl bate de câte ori îl prinde. Multe episoade sunt inspirate din viața adevăratului Louie Anderson, un comediant american care apare la începutul episoadelor și care le vorbește telespectatorilor. Louie Anderson a și regizat toate episoadele.
Louie este un copil un pic grăsuț care învață de-a lungul episoadelor lecții de viață importante. Serialul este o combinație reușită de întâmplări din care înveți ceva, cu comedia care te bine dispune și acțiunea care te captează.
Andy Anderson este tatăl acestuia, veteran de război. Andy este tipul omului lăudăros și exagerează de fiecare dată inventând povești din război în care el salvează întreaga omenire. El a lucrat, de fapt, ca bucătar. Mașina acestuia este un Rambler clasic la care nu ar renunța pentru nimic în lume. Aura Anderson este mama lui Louie, o femeie cumsecade, dar și o mamă extrem de iubitoare care ar face orice pentru copiii ei. Tommy Anderson este frățiorul mai mic al lui Louie. Este naiv, iar Louie îl păcălește de multe ori.
Louie's dad gets fired so the entire family tries to think of ways to save money until he can get back on his feet. Meanwhile, summer vacation has started and Louie is looking forward to three months of swimming and freedom...until his Dad, starved for things to keep himself busy, decides that Louie is going to help him do every fix-it job around the house.
Louie Anderson tells the story of a typical Christmas season when growing up in Cedar Knolls, Wisconsin during his childhood. Young Louie and his family go through the usual routine every family goes through during the season--with some hilarious results! Everything from buying a Christmas tree for the steep (at that time) price of $35, to putting up Christmas decorations for a lonely neighbor (who turns out to be Jewish), to actually opening presents on Christmas Day.
Louie makes a deal with his Dad to get out of his much-hated gym class if he agrees to play little league baseball. Much to Louie's dismay and bad luck, his baseball coach ends up being his tyranical gym teacher. After the coach is hit in the head by Louie's bat during a game Louie's dad Andy steps in as the coach and whips the team into shape in true military fashion--literally. While Andy is teaching the team battle strategies, Louie's mom teaches them actually baseball tips and tricks on the side. Of course in the end, Louie's team ends up in the big championship game and the team's newfound skills are put to the test.
When Louie's head swells up to gigantic red proportions, he knows there is something wrong, but does not want to face the awful possibility that he has allergies and must, therefore, get an allergy shot!
Louie, upset with being cast as the Turkey every year, single-handedly ruins the annual Cedar Knolls Elementary Thanksgiving Pageant. The principal decides that as punishment Louie needs to give a presentation on the meaning of Thanksgiving the Monday after the Thanksgiving holiday weekend. Louie tries to figure out the meaning of the holiday while his house is flooded with guests for Thanksgiving dinner, each of whom have their own unique interpretation of the holiday.
Louie is going to woods with father and his friends to catch deers.But one deer follows Louie and Louie makes a new friend,deer.When they go home late at night,deer follows them.Next day,they find out that deer is in their house.It is hrad for Andy,but he decides to keep deer.But,after deer finds out that he can't sleep anywhere he goes away...
The winter carnival begins in Cedar Knoll and The Anderson family loses every competition they enter. Meanwhile, Louie develops a crush on Jeannie's sister and tries to learn how to skate to get close to her.
The Anderson family goes to a fair where Aura tries to win the best cooking contest, and Andy wins a pig. Meanwhile, Tommy gets upset because Louie always takes him to the childish fair rides.