Povestită atât din punctul de vedere al detectivilor de omucideri și narcotice din Baltimore, cât și al țintelor acestora, serialul surprinde un univers în care războiul național împotriva drogurilor a devenit o birocrație permanentă, auto-susținută, iar distincțiile dintre bine și rău sunt în mod obișnuit șterse.
"No one wins. One side just loses more slowly." - Prez
Freamon and Greggs move to Homicide, while Herc and Dozerman join Marimow in the lackluster Major Crimes Unit. Cutty gets a "custodial" job at Tilghman School picking up truants, but struggles to make progress while trying to mentor Michael. Bubbles works to get Sherrod back in school as an 8th grader. Burrell finds a way to sabotage the state-witness murder investigation before the election, impacting Greggs. Prez's struggles as a teacher continue while Bodie finds himself working for a new "company". Meanwhile, Colvin pitches his pilot program to the middle school and Carcetti meets with a constituency when he knows that they won't support him regardless of what he says. Randy is faced with a dilemma after being busted for his candy scam and Proposition Joe plays Marlo in a high-stakes heist.
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